GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs35123781 | 1 | rs600848 | chr5:139057270 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.62 | 0.000321 | Schizophrenia |
| THCA | cis | rs515910 | 1 | rs601019 | chr10:105976452 | C10orf79 | chr10:105889647-105992120:- | -0.24 | -7.91 | 1.85E-14 | Attention deficit hyperactivity disorder |
| THCA | cis | rs2613514 | 1 | rs60105040 | chr17:76098948 | TMC6 | chr17:76108999-76128488:- | 0.18 | 3.54 | 0.000434 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs10789491 | 1 | rs601060 | chr1:47139580 | CYP4B1 | chr1:47264670-47285020:+ | -0.21 | -3.36 | 0.000849 | Response to hepatitis C treatment |
| THCA | cis | rs10789491 | 1 | rs601060 | chr1:47139580 | CYP4Z1 | chr1:47533160-47583992:+ | -0.26 | -3.95 | 8.97E-5 | Response to hepatitis C treatment |
| THCA | cis | rs10789491 | 1 | rs601060 | chr1:47139580 | DMBX1 | chr1:46972668-46979884:+ | -0.23 | -4.04 | 6.11E-5 | Response to hepatitis C treatment |
| THCA | cis | rs6011674 | 1 | rs6011691 | chr20:61867454 | BIRC7 | chr20:61867276-61871853:+ | 0.31 | 3.82 | 0.000149 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs6011674 | 1 | rs6011691 | chr20:61867454 | NKAIN4 | chr20:61872137-61885892:- | 0.31 | 3.5 | 0.000511 | Response to cytadine analogues (cytosine arabinoside) |
| THCA | cis | rs6472235 | 1 | rs60120959 | chr8:66799706 | PDE7A | chr8:66629906-66753755:- | 0.16 | 3.58 | 0.000383 | Myopia (pathological) |
| THCA | cis | rs6012564 | 1 | rs6012564 | chr20:47541600 | ARFGEF2 | chr20:47538275-47653229:+ | -0.12 | -3.92 | 0.000103 | Anger |
| THCA | cis | rs6012564 | 1 | rs6012564 | chr20:47541600 | CSE1L | chr20:47662838-47713484:+ | 0.41 | 10.17 | 3.84E-22 | Anger |
| THCA | cis | rs237743 | 1 | rs6012617 | chr20:47837126 | DDX27 | chr20:47835832-47860612:+ | -0.25 | -4.59 | 5.56E-6 | Height |
| THCA | cis | rs10518128 | 1 | rs60126902 | chr4:75710822 | BTC | chr4:75671448-75719882:- | 0.2 | 3.92 | 0.000103 | Electroencephalogram traits |
| THCA | cis | rs35123781 | 1 | rs601324 | chr5:139057179 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.62 | 0.000321 | Schizophrenia |
| THCA | cis | rs35123781 | 1 | rs601336 | chr5:139057167 | DNAJC18 | chr5:138747381-138775139:- | 0.16 | 3.58 | 0.000373 | Schizophrenia |